La tragedia della Metropolitana di Roma
L’ultimo metrò di una grande ricercatrice
Alessandra Lisi studiava le malformazioni fetali
Ecco la ricerca pubblicata
proprio a ottobre 2006
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banca dati Medline Express
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18 OTTOBRE 2006
Trends of selected malformations in relation to
folic acid recommendations and fortification: An international assessment.
Birth Defects Res A Clin Mol
Teratol. 2006
Oct 6;
Department of Pediatrics, University of Utah
and Utah Birth Defect Network, Salt Lake City, Utah.
BACKGROUND: Two crucial issues relative to the
benefits and impact of folic acid in the prevention of birth defects are
whether supplementation recommendations alone, without fortification, are
effective in reducing the population-wide rates of neural tube defects (NTDs), and
whether such policies can reduce the occurrence of other birth defects. Using
data from 15 registries, we assessed rates and trends of 14 major defects,
including NTDs, in areas with official recommendations or fortification to
assess the effectiveness of recommendations and fortification on a wide range
of major birth defects. METHODS: We evaluated surveillance data through 2003 on
major birth defects from population-based registries from Europe, North
America, and Australia. All included ascertainment of pregnancy terminations
(where legal). Trends before and after policies or fortification were assessed
via Poisson regression and were compared via rate ratios. RESULTS: Significant
changes in trends were seen for NTDs in areas with fortification but not in
areas with supplementation recommendations alone. For other major birth
defects, there was an overall lack of major trend changes after recommendations
or fortification. However, some significant declines were observed for select
birth defects in individual areas. CONCLUSIONS: Recommendations alone remain an
ineffective approach in translating the known protective effect of folic acid
in population-wide decline in NTD rates. Fortification appears to be effective
in reducing NTDs. The effect on other birth defects remains unclear. Birth
Defects Research (Part A), 2006. (c) 2006 Wiley-Liss, Inc.
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